Online ISSN: 1945-4589

Special Collection on Tumor Suppressors


PDF EPUB

iBooks, GooglePlay Books and Kindle Fire eReaders are the best way to view Epub formats

Explore This Issue

Adaptive sequence convergence of the tumor suppressor ADAMTS9 between small-bodied mammals displaying exceptional longevity

Matthew J. Lambert, Christine V. Portfors,
https://doi.org/10.18632/aging.101180 pp 573—582
View Abstract PDF Full-Text How to Cite

Mir 145/143: tumor suppressor, oncogenic microenvironmental factor or ...both?

Mario Cioce, Sabrina Strano, Paola Muti, Giovanni Blandino,
https://doi.org/10.18632/aging.100965 pp 1153—1155
PDF How to Cite

p63 expression confers significantly better survival outcomes in high-risk diffuse large B-cell lymphoma and demonstrates p53-like and p53-independent tumor suppressor function

Zijun Y. Xu-Monette, Shanxiang Zhang, Xin Li, Ganiraju C. Manyam, Xiao-xiao Wang, Yi Xia, Carlo Visco, Alexandar Tzankov, Li Zhang, Santiago Montes-Moreno, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W.L. Choi, J. Han van Krieken, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Xiaoying Zhao, Michael B. Møller, Ben M. Parsons, Jane N. Winter, Miguel A. Piris, L. Jeffrey Medeiros, Ken H. Young,
https://doi.org/10.18632/aging.100898 pp 345—365
View Abstract PDF Full-Text How to Cite

The PTEN tumor suppressor gene and its role in lymphoma pathogenesis

Xiaoxiao Wang, Huiqiang Huang, Ken H. Young,
https://doi.org/10.18632/aging.100855 pp 1032—1049
View Abstract PDF Full-Text How to Cite

The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells

Sarah Waye, Aisha Naeem, Muhammad Umer Choudhry, Erika Parasido, Lucas Tricoli, Angiela Sivakumar, John P. Mikhaiel, Venkata Yenugonda, Olga C. Rodriguez, Sana D. Karam, Brian R. Rood, Maria Laura Avantaggiati, Chris Albanese,
https://doi.org/10.18632/aging.100831 pp 854—867
View Abstract PDF Full-Text How to Cite

MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans

Michèle Riesen, Inna Feyst, Nattaphong Rattanavirotkul, Marina Ezcurra, Jennifer M.A. Tullet, Irene Papatheodorou, Matthias Ziehm, Catherine Au, Ann F. Gilliat, Josephine Hellberg, Janet M. Thornton, David Gems,
https://doi.org/10.18632/aging.100638 pp 98—117
View Abstract PDF Full-Text How to Cite

Immortalization of MEF is characterized by the deregulation of specific miRNAs with potential tumor suppressor activity

Milena Rizzo, Monica Evangelista, Marcella Simili, Laura Mariani, Letizia Pitto, Giuseppe Rainaldi,
https://doi.org/10.18632/aging.100353 pp 665—671
View Abstract PDF Full-Text How to Cite

Insights from model organisms on the functions of the tumor suppressor protein LKB1: Zebrafish chips in

Yme U. van der Velden, Anna-Pavlina G. Haramis,
https://doi.org/10.18632/aging.100319 pp 363—367
View Abstract PDF Full-Text How to Cite

MKK4 as oncogene or tumor suppressor: In cancer and senescence, the story's getting old

Steven C. Cunningham, Eike Gallmeier, Scott E. Kern,
https://doi.org/10.18632/aging.100233 pp 752—753
PDF How to Cite

Tumor suppressors revival in CLL

Giovanna Carrà, Riccardo Taulli, Alessandro Morotti,
https://doi.org/10.18632/aging.101258 pp 1473—1474
PDF How to Cite

SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes

Emmanuelle Saint-Germain, Lian Mignacca, Mathieu Vernier, Diwakar Bobbala, Subburaj Ilangumaran, Gerardo Ferbeyre,
https://doi.org/10.18632/aging.101306 pp 2137—2162
View Abstract PDF Full-Text How to Cite

Premature aging and cancer development in transgenic mice lacking functional CYLD

Josefa P. Alameda, Ángel Ramírez, Rosa A. García-Fernández, Manuel Navarro, Angustias Page, José C. Segovia, Rebeca Sanchez, Cristian Suárez-Cabrera, Jesús M. Paramio, Ana Bravo, M. Jesús Fernández-Aceñero, M. Llanos Casanova,
https://doi.org/10.18632/aging.101732 pp 127—159
View Abstract PDF Full-Text How to Cite

Long noncoding RNA LINC00963 induces NOP2 expression by sponging tumor suppressor miR-542-3p to promote metastasis in prostate cancer

Feng Sun, Ke Wu, Zhixian Yao, Xingyu Mu, Zhong Zheng, Menghao Sun, Yong Wang, Zhihong Liu, Yiyong Zhu,
https://doi.org/10.18632/aging.103236 pp 11500—11516
View Abstract PDF Full-Text How to Cite

The association between KLF4 as a tumor suppressor and the prognosis of hepatocellular carcinoma after curative resection

Min Xue, Chenhao Zhou, Yan Zheng, Ziping Zhang, Shun Wang, Yan Fu, Manar Atyah, Xiaolong Xue, Le Zhu, Qiongzhu Dong, Huliang Jia, Ning Ren, Ruolei Hu,
https://doi.org/10.18632/aging.103592 pp 15566—15580
View Abstract PDF Full-Text How to Cite

Aerobic exercise induces tumor suppressor p16INK4a expression of endothelial progenitor cells in human skeletal muscle

Jinfu Wu, I-Shiung Cheng, Suchada Saovieng, Wei-Horng Jean, Chung-Lan Kao, Yung-Yang Liu, Chih-Yang Huang, Tania Xu Yar Lee, John L. Ivy, Chia-Hua Kuo,
https://doi.org/10.18632/aging.103763 pp 20226—20234
View Abstract PDF Full-Text How to Cite

CPEB3 functions as a tumor suppressor in colorectal cancer via JAK/STAT signaling

Yuxin Fang, Qian Zhong, Yadong Wang, Chuncai Gu, Side Liu, Aimin Li, Qun Yan,
https://doi.org/10.18632/aging.103893 pp 21404—21422
View Abstract PDF Full-Text How to Cite

Extracellular vesicle derived miR-544 downregulates expression of tumor suppressor promyelocytic leukemia zinc finger resulting in increased peritoneal metastasis in gastric cancer

Wencheng Kong, Xinchun Liu, Guang Yin, Sixin Zheng, Akao Zhu, Panpan Yu, Yuqiang Shan, Rongchao Ying, Jian Zhang,
https://doi.org/10.18632/aging.104082 pp 24009—24022
View Abstract PDF Full-Text How to Cite

MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role

Yi-Jing Hsiao, Wen-Hsin Chang, Hsuan-Yu Chen, Yin-Chen Hsu, Su-Chin Chiu, Ching-Cheng Chiang, Gee-Chen Chang, Yi-Ju Chen, Chia-Yu Wang, Yan-Ming Chen, Chien-Yu Lin, Yu-Ju Chen, Pan-Chyr Yang, Jeremy J.W. Chen, Sung-Liang Yu,
https://doi.org/10.18632/aging.202171 pp 646—674
View Abstract PDF Full-Text How to Cite

Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma

Xiao Dong, Yang Han, Encheng Zhang, Yuqi Wang, Pingzhao Zhang, Chenji Wang, Lin Zhong, Qi Li,
https://doi.org/10.18632/aging.202823 pp 10603—10618
View Abstract PDF Full-Text How to Cite

SPRY4 suppresses proliferation and induces apoptosis of colorectal cancer cells by repressing oncogene EZH2

Jia Guo, Huadong Zhu, Qiang Li, Jianhua Dong, Wei Xiong, Kun Yu,
https://doi.org/10.18632/aging.202859 pp 11665—11677
View Abstract PDF Full-Text How to Cite

miR-144-3p inhibited the growth, metastasis and epithelial-mesenchymal transition of colorectal adenocarcinoma by targeting ZEB1/2

Taiyuan Li, Cheng Tang, Zhixiang Huang, Lingling Yang, Hua Dai, Bo Tang, Benping Xiao, Jianfeng Li, Xiong Lei,
https://doi.org/10.18632/aging.203225 pp 17349—17369
View Abstract PDF Full-Text How to Cite

CircSPIDR acts as a tumour suppressor in cervical adenocarcinoma by sponging miR-431-5p and regulating SORCS1 and CUBN expression

Junfen Xu, Weiguo Lu,
https://doi.org/10.18632/aging.203283 pp 18340—18359
View Abstract PDF Full-Text How to Cite

Downregulation of ZC3H13 by miR-362-3p/miR-425-5p is associated with a poor prognosis and adverse outcomes in hepatocellular carcinoma

Shuang Wu, Shihai Liu, Yongxian Cao, Geng Chao, Peng Wang, Huazheng Pan,
https://doi.org/10.18632/aging.203939 pp 2304—2319
View Abstract PDF Full-Text How to Cite

miRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer

Guangyu Gao, Xiaofei Guo, Wenyong Gu, Yufeng Lu, Zhigang Chen,
https://doi.org/10.18632/aging.203998 pp 3387—3399
View Abstract PDF Full-Text How to Cite

Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties

James A. McCubrey, Akshaya K. Meher, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Michelle M. LaHair, Richard A. Franklin, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Fulvio Barbaro, Przemysław Duda, Agnieszka Gizak,
https://doi.org/10.18632/aging.204038 pp 3365—3386
View Abstract PDF Full-Text How to Cite