Review Volume 3, Issue 4 pp 363—367
Insights from model organisms on the functions of the tumor suppressor protein LKB1: Zebrafish chips in
- 1 Department of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands
Received: April 12, 2011 Accepted: April 25, 2011 Published: April 26, 2011https://doi.org/10.18632/aging.100319
How to Cite
The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy-metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue-specific and context-dependent effectors.