Research Paper Volume 13, Issue 12 pp 16316—16340

Comprehensive signature analysis of drug metabolism differences in the White, Black and Asian prostate cancer patients

Key functional modules with ethnic differences were identified for each omics. (A) Multi-omics key functional modules core genes differences analysis for races, as both single gene or total, which were shown in hot map. (B) The core genes of mRNA key functional module (drug metabolism) differences analysis for RACES as both single gene or total. (C) The core genes of miRNA key functional module (platinum resistance and antineoplastic agent response) differences analysis for RACES as both single gene or total. (D) The core genes of lncRNA key functional module (endocrine therapy resistance) differences analysis for RACES as both single gene or total. (E) The core genes of methylation key functional modules (drug metabolism, molecular targeted therapy and response to radiation) differences analysis for RACES as both single gene or total. (Notes: mRNA, miRNA, lncRNA, methylation expressed as the mean value of the core genes of each key functional module, methylation-DM expressed as the mean value of drug mentalism-related methylations, miRNA 1 expressed as the mean value of antineoplastic agent response related core miRNAs, miRNA 2 expressed as the mean value of platinum resistance related core miRNAs, B-A, W-A, W-B expressed as the mean value of core genes of each key functional modules which significant in Black people VS Asian people, White people VS Asian people, White people VS Black people, respectively).

Figure 3. Key functional modules with ethnic differences were identified for each omics. (A) Multi-omics key functional modules core genes differences analysis for races, as both single gene or total, which were shown in hot map. (B) The core genes of mRNA key functional module (drug metabolism) differences analysis for RACES as both single gene or total. (C) The core genes of miRNA key functional module (platinum resistance and antineoplastic agent response) differences analysis for RACES as both single gene or total. (D) The core genes of lncRNA key functional module (endocrine therapy resistance) differences analysis for RACES as both single gene or total. (E) The core genes of methylation key functional modules (drug metabolism, molecular targeted therapy and response to radiation) differences analysis for RACES as both single gene or total. (Notes: mRNA, miRNA, lncRNA, methylation expressed as the mean value of the core genes of each key functional module, methylation-DM expressed as the mean value of drug mentalism-related methylations, miRNA 1 expressed as the mean value of antineoplastic agent response related core miRNAs, miRNA 2 expressed as the mean value of platinum resistance related core miRNAs, B-A, W-A, W-B expressed as the mean value of core genes of each key functional modules which significant in Black people VS Asian people, White people VS Asian people, White people VS Black people, respectively).