Research Paper Volume 13, Issue 12 pp 16381—16403

Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy

Effects of acacetin on cardiac function in a mouse aging model induced by D-galactose. (A). Back hair loss (white arrow) was observed in mice with subcutaneous injection of D-galactose (D-gal, 150 mg/kg/day), but not in D-galactose mice with oral acacetin (50 mg/kg/day). (B) Representative echocardiography images of control mouse, D-galactose mouse and D-galactose mouse with oral acacetin (50 mg/kg/day). (C) Echocardiograph parameters: left ventricular ejection fraction (EF), fractional shortening (FS), diastolic left ventricular anterior wall thickness (LVAWd), diastolic left ventricular posterior wall thickness (LVPWd), thickness of interventricular septal end diastole (IVSd), and left ventricular end-systolic diameter (LVESD) in mice without (control) or with D-galactose or D-galactose plus oral acacetin 10, 20 or 50 mg/kg/day (n = 10-12, **P #P ##P

Figure 1. Effects of acacetin on cardiac function in a mouse aging model induced by D-galactose. (A). Back hair loss (white arrow) was observed in mice with subcutaneous injection of D-galactose (D-gal, 150 mg/kg/day), but not in D-galactose mice with oral acacetin (50 mg/kg/day). (B) Representative echocardiography images of control mouse, D-galactose mouse and D-galactose mouse with oral acacetin (50 mg/kg/day). (C) Echocardiograph parameters: left ventricular ejection fraction (EF), fractional shortening (FS), diastolic left ventricular anterior wall thickness (LVAWd), diastolic left ventricular posterior wall thickness (LVPWd), thickness of interventricular septal end diastole (IVSd), and left ventricular end-systolic diameter (LVESD) in mice without (control) or with D-galactose or D-galactose plus oral acacetin 10, 20 or 50 mg/kg/day (n = 10-12, **P < 0.01 vs. control group. #P < 0.05, ##P < 0.01 vs D-gal group).