Research Paper Volume 13, Issue 12 pp 16471—16484

LncRNA HCG11/miR-579-3p/MDM2 axis modulates malignant biological properties in pancreatic carcinoma via Notch/Hes1 signaling pathway

High expression of HCG11 was observed in pancreatic carcinoma tissues and cells. (A) qPCR assay was performed to detect HCG11 expression in 20 pairs of pancreatic carcinoma tissues and corresponding normal tissues. ***pB) HCG11 expression in pancreatic carcinoma cell lines (BxPC-3, Capan-2, SW1990, PANC-1 and AsPC-1) was also detected by qPCR. **p***pC, D) With transfected si-HCG11-1 or si-HCG11-2 in PANC-1 and AsPC-1 cells, qPCR was applied to detect HCG11 expression. **p***p

Figure 1. High expression of HCG11 was observed in pancreatic carcinoma tissues and cells. (A) qPCR assay was performed to detect HCG11 expression in 20 pairs of pancreatic carcinoma tissues and corresponding normal tissues. ***p<0.001 vs. normal tissues. (B) HCG11 expression in pancreatic carcinoma cell lines (BxPC-3, Capan-2, SW1990, PANC-1 and AsPC-1) was also detected by qPCR. **p<0.01, ***p<0.001 vs. HPDE6-C7. (C, D) With transfected si-HCG11-1 or si-HCG11-2 in PANC-1 and AsPC-1 cells, qPCR was applied to detect HCG11 expression. **p<0.01, ***p<0.001 vs. siRNA NC.