Research Paper Volume 13, Issue 12 pp 16500—16512

Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer

Knockdown of circKIF4A attenuates the proliferation of papillary thyroid cancer cells. (A) Knockdown effect of circKIF4A was assessed in TPC-1 and KAT-5 cell line. (B) CCK-8 assays evaluated cell proliferation after knockdown of circKIF4A. (C) Colony formation assays revealed that circKIF4A silencing suppressed cell colony formatting ability. (D) Mouse xenograft models were established. Tumor volume was estimated in every four days. (E) GSH/GSSG ratio was detected.

Figure 2. Knockdown of circKIF4A attenuates the proliferation of papillary thyroid cancer cells. (A) Knockdown effect of circKIF4A was assessed in TPC-1 and KAT-5 cell line. (B) CCK-8 assays evaluated cell proliferation after knockdown of circKIF4A. (C) Colony formation assays revealed that circKIF4A silencing suppressed cell colony formatting ability. (D) Mouse xenograft models were established. Tumor volume was estimated in every four days. (E) GSH/GSSG ratio was detected.