Research Paper Volume 13, Issue 12 pp 16713—16732

Immune infiltration and a ferroptosis-associated gene signature for predicting the prognosis of patients with endometrial cancer

Construction of the signature. (A) The prognostic analyses for eight ferroptosis-related genes in the training cohort of endometrial cancer using a univariate Cox regression model. Hazard ratio >1 represented risk factors for survival and hazard ratio B) Heatmap of eight ferroptosis-related genes in 23 normal samples and 272 endometrial cancer samples. (C) Optimal parameter (λ) selected in the LASSO Cox regression model based on the minimum criteria. (D) The LASSO coefficient profiles of the eight ferroptosis-related genes signature. (E) The distribution and median value of the risk scores in the training cohort. (F) The distribution and median value of the risk scores in the training cohort. (G) Survival statuses of endometrial cancer patients in the training cohort. (H) Survival statuses of endometrial cancer patients in the testing cohort.

Figure 1. Construction of the signature. (A) The prognostic analyses for eight ferroptosis-related genes in the training cohort of endometrial cancer using a univariate Cox regression model. Hazard ratio >1 represented risk factors for survival and hazard ratio <1 represented protective factors for survival. (B) Heatmap of eight ferroptosis-related genes in 23 normal samples and 272 endometrial cancer samples. (C) Optimal parameter (λ) selected in the LASSO Cox regression model based on the minimum criteria. (D) The LASSO coefficient profiles of the eight ferroptosis-related genes signature. (E) The distribution and median value of the risk scores in the training cohort. (F) The distribution and median value of the risk scores in the training cohort. (G) Survival statuses of endometrial cancer patients in the training cohort. (H) Survival statuses of endometrial cancer patients in the testing cohort.