Theory Article Volume 13, Issue 12 pp 15699—15749

Shifting epigenetic contexts influence regulatory variation and disease risk

Cross-tissue accessibility. (A) Representative heatmap of Dnase-I accessibility for regions significantly different between fetal/adult tissues. Color scale indicates magnitude of chromatin accessibility signal (see Supplementary Methods). Horizontal lines denote defined fetal-biased (left) and adult-biased regions. (B) Genomic distribution of regions changing accessibility in fetal and adult comparison. Red/blue: density of defined differentially-accessible regions. Solid black line: relative proportion of regions more accessible in adult (top) or fetal (bottom) tissues. First five autosomes shown (see Supplementary Figure 2). (C) The proportion of defined altered-accessibility regions between adult and fetal samples for indicated tissues which are unique to that tissue, or captured in the pan-tissue set. (D) Overlaps between regions defined as differentially-accessible in fetal/adult comparison and those defined in the young/old-age comparison. Directionality in accessibility change is significantly shared (see Supplementary Table 1). Related content can be found in Supplementary Information, Supplementary Figures 1–6 and Supplementary Tables 1, 2.

Figure 1. Cross-tissue accessibility. (A) Representative heatmap of Dnase-I accessibility for regions significantly different between fetal/adult tissues. Color scale indicates magnitude of chromatin accessibility signal (see Supplementary Methods). Horizontal lines denote defined fetal-biased (left) and adult-biased regions. (B) Genomic distribution of regions changing accessibility in fetal and adult comparison. Red/blue: density of defined differentially-accessible regions. Solid black line: relative proportion of regions more accessible in adult (top) or fetal (bottom) tissues. First five autosomes shown (see Supplementary Figure 2). (C) The proportion of defined altered-accessibility regions between adult and fetal samples for indicated tissues which are unique to that tissue, or captured in the pan-tissue set. (D) Overlaps between regions defined as differentially-accessible in fetal/adult comparison and those defined in the young/old-age comparison. Directionality in accessibility change is significantly shared (see Supplementary Table 1). Related content can be found in Supplementary Information, Supplementary Figures 16 and Supplementary Tables 1, 2.