Research Paper Volume 13, Issue 13 pp 17901—17913

Chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3

CQ suppress the OS cell migration, invasion, and lamellipodia formation. (A, B) Migration ability of OS cells was inhibited gradually by CQ with the increasing of concentration (**P ***p n = 3). (C, D) Invasion ability of OS cells was inhibited gradually by CQ with the increasing of concentration (***p n = 3). (E, F) Cytoskeletal assay showed that the lamellipodia formation of OS cells was inhibited gradually by CQ with the increasing of concentration (***p n = 3). The data were expressed as the mean ± SEM.

Figure 2. CQ suppress the OS cell migration, invasion, and lamellipodia formation. (A, B) Migration ability of OS cells was inhibited gradually by CQ with the increasing of concentration (**P < 0.01; ***p < 0.001; n = 3). (C, D) Invasion ability of OS cells was inhibited gradually by CQ with the increasing of concentration (***p < 0.001; n = 3). (E, F) Cytoskeletal assay showed that the lamellipodia formation of OS cells was inhibited gradually by CQ with the increasing of concentration (***p < 0.001; n = 3). The data were expressed as the mean ± SEM.