Research Paper Volume 13, Issue 13 pp 17901—17913

Chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3

p-STAT3 expression was elevated by IHC in OS and associated with poor prognosis. (A) Kaplan–Meier curves showed the p-STAT3 expression on overall survival in 30 OS patients (*p n = 30). (B) ROC curve of predictive value of p-STAT3 expression on lung metastasis of OS patients (*p n = 30). (C) IHC staining of p-STAT3 in OS samples (**p n = 30). The data were expressed as the mean ± SD.

Figure 5. p-STAT3 expression was elevated by IHC in OS and associated with poor prognosis. (A) Kaplan–Meier curves showed the p-STAT3 expression on overall survival in 30 OS patients (*p < 0.05; n = 30). (B) ROC curve of predictive value of p-STAT3 expression on lung metastasis of OS patients (*p < 0.05; n = 30). (C) IHC staining of p-STAT3 in OS samples (**p < 0.01; n = 30). The data were expressed as the mean ± SD.