Research Paper Volume 13, Issue 13 pp 17901—17913

Chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3

The schematic of the hypothetic mechanisms of CQ effects on p-STAT3/Bcl-2/Caspase3 pathway. CQ inhibited the phosphorylation of STAT3 and then by downregulating the expression of p-STAT3 to suppress the CD31 to inhibit angiopoiesis, and suppress N-cadherin, Vimentin, and Slug as well as downregulate E-cadherin to inhibit EMT and metastasis, and suppress Ki67 to inhibit proliferation, as well as upregulate Bax and Caspase3 and downregulate Bcl-2 to induce apoptosis of OS cells.

Figure 7. The schematic of the hypothetic mechanisms of CQ effects on p-STAT3/Bcl-2/Caspase3 pathway. CQ inhibited the phosphorylation of STAT3 and then by downregulating the expression of p-STAT3 to suppress the CD31 to inhibit angiopoiesis, and suppress N-cadherin, Vimentin, and Slug as well as downregulate E-cadherin to inhibit EMT and metastasis, and suppress Ki67 to inhibit proliferation, as well as upregulate Bax and Caspase3 and downregulate Bcl-2 to induce apoptosis of OS cells.