Research Paper Volume 13, Issue 13 pp 17901—17913

Chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3

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Figure 7. The schematic of the hypothetic mechanisms of CQ effects on p-STAT3/Bcl-2/Caspase3 pathway. CQ inhibited the phosphorylation of STAT3 and then by downregulating the expression of p-STAT3 to suppress the CD31 to inhibit angiopoiesis, and suppress N-cadherin, Vimentin, and Slug as well as downregulate E-cadherin to inhibit EMT and metastasis, and suppress Ki67 to inhibit proliferation, as well as upregulate Bax and Caspase3 and downregulate Bcl-2 to induce apoptosis of OS cells.