Research Paper Volume 13, Issue 13 pp 17227—17236

miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts

MiR-let-7c-5p and miR-149-5p regulate IL-1β, IL-6 and TNF-α expression in OASFs and RASFs. After transfecting OASFs (A, B) and RASFs (C, D) with the miR-let-7c-5p and miR-149-5p mimics or their respective inhibitors, IL-1β, IL-6 and TNF-α expression was examined by qPCR.

Figure 3. MiR-let-7c-5p and miR-149-5p regulate IL-1β, IL-6 and TNF-α expression in OASFs and RASFs. After transfecting OASFs (A, B) and RASFs (C, D) with the miR-let-7c-5p and miR-149-5p mimics or their respective inhibitors, IL-1β, IL-6 and TNF-α expression was examined by qPCR.