Research Paper Volume 13, Issue 13 pp 17227—17236

miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts

Anti-inflammatory agents reduce proinflammatory cytokine production in OASFs and RASFs. After treating OASFs (A–F) and RASFs (G–L) with dexamethasone, celecoxib, or indomethacin (1–50 μM), Western blot and qPCR assays quantified the levels of IL-1β, IL-6 and TNF-α expression.

Figure 5. Anti-inflammatory agents reduce proinflammatory cytokine production in OASFs and RASFs. After treating OASFs (AF) and RASFs (GL) with dexamethasone, celecoxib, or indomethacin (1–50 μM), Western blot and qPCR assays quantified the levels of IL-1β, IL-6 and TNF-α expression.