Research Paper Volume 13, Issue 13 pp 17285—17301

Knockdown of lncRNA ZNRD1-AS1 suppresses gastric cancer cell proliferation and metastasis by targeting the miR-9-5p/HSP90AA1 axis

miR-9-5p inhibitor rescues the effect of ZNRD1-AS1 knockdown on malignant characteristics and apoptosis. miR-9-5p inhibitor was cotransfected into MGC803 and BGC823 cells; with cotransfection of siZNRD1-AS1 and miR-NC inhibitor as control. Cell proliferation (A) and apoptosis (B) were analyzed by CCK8 assays and flow cytometry, respectively. Cell invasion (C) and migration (D) were analyzed by Transwell assays. Left panels show representative micrographs. Right panels show statistical results. *p

Figure 4. miR-9-5p inhibitor rescues the effect of ZNRD1-AS1 knockdown on malignant characteristics and apoptosis. miR-9-5p inhibitor was cotransfected into MGC803 and BGC823 cells; with cotransfection of siZNRD1-AS1 and miR-NC inhibitor as control. Cell proliferation (A) and apoptosis (B) were analyzed by CCK8 assays and flow cytometry, respectively. Cell invasion (C) and migration (D) were analyzed by Transwell assays. Left panels show representative micrographs. Right panels show statistical results. *p <0.05, for siZNRD1-AS1 + miR-9-5p inhibitor vs. siZNRD1-AS1 + miR-NC inhibitor.