Research Paper Volume 13, Issue 13 pp 17316—17327

Anoctamin 5 promotes osteosarcoma development by increasing degradation of Nel-like proteins 1 and 2

Inhibition of ANO5 decreased cell proliferation and NELL1 and NELL2 expression in vivo. (A, B) ANO5 knockdown decreased HOS cell proliferation in vivo. (C) IHC showed that inhibition of ANO5 decreased the expression of KI67 and increased the expression of NELL1 and NELL2. *, PP

Figure 5. Inhibition of ANO5 decreased cell proliferation and NELL1 and NELL2 expression in vivo. (A, B) ANO5 knockdown decreased HOS cell proliferation in vivo. (C) IHC showed that inhibition of ANO5 decreased the expression of KI67 and increased the expression of NELL1 and NELL2. *, P<0.05; **, P<0.01.