Research Paper Volume 13, Issue 12 pp 16786—16803

Transcription factor PAX4 facilitates gastric cancer progression through interacting with miR-27b-3p/Grb2 axis

PAX4 overexpression promoted GC tumor growth in vivo. (A–B) Subcutaneous tumor records of the si-PAX4 group and PAX4 ov group. (C–D) The average tumor volume curves indicated that silencing PAX4 can inhibit tumor growth and upregulation of PAX4 can promote tumor growth. (E–F) Knockdown of PAX4 led to the lighter average tumor weight (P = 0.0039) and upregulating PAX4 led to an average heavier tumor weight (P = 0.0017).

Figure 3. PAX4 overexpression promoted GC tumor growth in vivo. (AB) Subcutaneous tumor records of the si-PAX4 group and PAX4 ov group. (CD) The average tumor volume curves indicated that silencing PAX4 can inhibit tumor growth and upregulation of PAX4 can promote tumor growth. (EF) Knockdown of PAX4 led to the lighter average tumor weight (P = 0.0039) and upregulating PAX4 led to an average heavier tumor weight (P = 0.0017).