Research Paper Volume 13, Issue 12 pp 16786—16803

Transcription factor PAX4 facilitates gastric cancer progression through interacting with miR-27b-3p/Grb2 axis

PAX4/miR-27b-3p/Grb2 regulatory loop activates the Ras-ERK pathway. Ras-ERK associated proteins (p-Raf, p-MEK, p-ERK, t-Raf, t-MEK, t-ERK), EMT pathway protein (Vimentin) and cyclin pathway-related protein (cyclinD1) and Bax apoptotic protein were determined using western blot.

Figure 7. PAX4/miR-27b-3p/Grb2 regulatory loop activates the Ras-ERK pathway. Ras-ERK associated proteins (p-Raf, p-MEK, p-ERK, t-Raf, t-MEK, t-ERK), EMT pathway protein (Vimentin) and cyclin pathway-related protein (cyclinD1) and Bax apoptotic protein were determined using western blot.