Research Paper Volume 13, Issue 12 pp 16816—16833

Celastrol protects against early brain injury after subarachnoid hemorrhage in rats through alleviating blood-brain barrier disruption and blocking necroptosis

Representative pictures of brains, SAH grade, mortalities and neurological scores at 72 h after SAH. (A) Typical brains of sham, SAH + vehicle, and SAH + Cel group. (B) The grade of SAH severity. (C) SAH-caused mortality rate. (D) Neurological scores at 24, 48 and 72 h after SAH induction. Data were presented as mean±SEM. n = 14. *P P #P

Figure 1. Representative pictures of brains, SAH grade, mortalities and neurological scores at 72 h after SAH. (A) Typical brains of sham, SAH + vehicle, and SAH + Cel group. (B) The grade of SAH severity. (C) SAH-caused mortality rate. (D) Neurological scores at 24, 48 and 72 h after SAH induction. Data were presented as mean±SEM. n = 14. *P < 0.05 versus sham, **P < 0.01 versus sham, #P < 0.05 versus SAH + vehicle.