Research Paper Volume 13, Issue 12 pp 16816—16833

Celastrol protects against early brain injury after subarachnoid hemorrhage in rats through alleviating blood-brain barrier disruption and blocking necroptosis

Celastrol decreased albumin leakage after SAH. (A) Protein levels of albumin in the ipsilateral basal cortex in sham, SAH + vehicle, and SAH + Cel groups at 72 h after SAH induction, detected by WB. (B) Representative histological slides of the albumin staining in the perivascular regions of the ipsilateral basal cortex in sham, SAH + vehicle, and SAH + Cel group. Data were presented as mean±SEM. n = 6. **P

Figure 4. Celastrol decreased albumin leakage after SAH. (A) Protein levels of albumin in the ipsilateral basal cortex in sham, SAH + vehicle, and SAH + Cel groups at 72 h after SAH induction, detected by WB. (B) Representative histological slides of the albumin staining in the perivascular regions of the ipsilateral basal cortex in sham, SAH + vehicle, and SAH + Cel group. Data were presented as mean±SEM. n = 6. **P < 0.01. Scale bar = 2 mm.