Research Paper Volume 13, Issue 12 pp 16816—16833

Celastrol protects against early brain injury after subarachnoid hemorrhage in rats through alleviating blood-brain barrier disruption and blocking necroptosis

Celastrol decreased neuroinflammation after SAH induction. (A) Representative WB of protein levels of IL-1β, IL-6 and TNF-α in the ipsilateral cortex in each group at 72 h after SAH induction. (B–D) The relative band densities of IL-1β, IL-6 and TNF-α. The densities of the protein bands were analyzed and normalized to β-actin, and compared to the mean value of the sham group. Data were presented as mean±SEM. n = 6. *P P

Figure 7. Celastrol decreased neuroinflammation after SAH induction. (A) Representative WB of protein levels of IL-1β, IL-6 and TNF-α in the ipsilateral cortex in each group at 72 h after SAH induction. (BD) The relative band densities of IL-1β, IL-6 and TNF-α. The densities of the protein bands were analyzed and normalized to β-actin, and compared to the mean value of the sham group. Data were presented as mean±SEM. n = 6. *P < 0.05, **P < 0.01.