Research Paper Volume 13, Issue 12 pp 15917—15941

Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization

Putative G4-forming sequences from the human, mouse, and rat Brca1 and their promoters fold into G4-DNA structures in vitro. (A) Sequences of putative G4-DNA-forming sequences from the human, mouse, and rat Brca1 and their promoters, along with their G4Hunter (GH) scores. (B, C) CD and TDS signatures of these G4-forming sequences (3 μM) in Caco.K10 buffer (10 mM lithium cacodylate buffer (pH 7.2) plus 10 mM KCl and 90 mM LiCl).

Figure 5. Putative G4-forming sequences from the human, mouse, and rat Brca1 and their promoters fold into G4-DNA structures in vitro. (A) Sequences of putative G4-DNA-forming sequences from the human, mouse, and rat Brca1 and their promoters, along with their G4Hunter (GH) scores. (B, C) CD and TDS signatures of these G4-forming sequences (3 μM) in Caco.K10 buffer (10 mM lithium cacodylate buffer (pH 7.2) plus 10 mM KCl and 90 mM LiCl).