Research Paper Volume 13, Issue 14 pp 18223—18237

Combination of rapamycin and SAHA enhanced radiosensitization by inducing autophagy and acetylation in NSCLC

Cytotoxic effects of combination treatment with RAPA or/and SAHA in NSCLC cells. Cell viabilities were assessed by the cell counting kit-8 (CCK-8). (A, B) Concentration-dependent effects of RAPA (A) and SAHA (B) on the viability of two NSCLC cells (A549, SK-MES-1) for 24h. *pC, D) Time-dependent effects of RAPA (100nmol/L) or/and SAHA (2.5μmol/L) on the viability of A549 (C) and SK-MES-1 (D) cells. *p#p

Figure 1. Cytotoxic effects of combination treatment with RAPA or/and SAHA in NSCLC cells. Cell viabilities were assessed by the cell counting kit-8 (CCK-8). (A, B) Concentration-dependent effects of RAPA (A) and SAHA (B) on the viability of two NSCLC cells (A549, SK-MES-1) for 24h. *p<0.05, RAPA or SAHA versus control. (C, D) Time-dependent effects of RAPA (100nmol/L) or/and SAHA (2.5μmol/L) on the viability of A549 (C) and SK-MES-1 (D) cells. *p<0.05, combined treatment versus single treatment, #p<0.05, 48h or 72h versus 24h.