Research Paper Volume 13, Issue 14 pp 18238—18256

Integrated analysis of m6A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension

(A) Changes of echocardiography in rats after intraperitoneal injection of monocrotaline (MCT) for 4 weeks. (B) The hemodynamic test results of the two groups. Compared with the control group, the right ventricular systolic pressure was significantly increased in the PAH group, and RV/ (LV + S) also increased in the PAH group. (C) Pulmonary artery HE staining images of the control group and PAH group were obtained under microscopy. Pulmonary artery remodeling was observed in PAH group compared with control group. *P P P P

Figure 1. (A) Changes of echocardiography in rats after intraperitoneal injection of monocrotaline (MCT) for 4 weeks. (B) The hemodynamic test results of the two groups. Compared with the control group, the right ventricular systolic pressure was significantly increased in the PAH group, and RV/ (LV + S) also increased in the PAH group. (C) Pulmonary artery HE staining images of the control group and PAH group were obtained under microscopy. Pulmonary artery remodeling was observed in PAH group compared with control group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.