Research Paper Volume 13, Issue 14 pp 18238—18256

Integrated analysis of m6A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension

Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses of coding genes harboring differentially methylated N6-methyladenosine sites. (A) Bar plot showing the top ten enrichment scores of the molecular function for the up-methylated genes. (B) Bar plot showing the top ten enrichment scores of molecular functions of the down-methylated genes. (C) The top ten gene ontology terms of biological processes were significantly enriched for the up-methylated genes. (D) The top ten gene ontology terms of biological process significantly enriched for down-methylated genes. (E) In the cellular component category, the lung tissues of rats mainly contain genes with DMMSs. (F) Bar plot showing the top ten enrichment scores of the significant enrichment pathway for the up-methylated genes. (G) Bar plot showing the top ten enrichment scores of the significant enrichment pathways of the down-methylated genes.

Figure 4. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses of coding genes harboring differentially methylated N6-methyladenosine sites. (A) Bar plot showing the top ten enrichment scores of the molecular function for the up-methylated genes. (B) Bar plot showing the top ten enrichment scores of molecular functions of the down-methylated genes. (C) The top ten gene ontology terms of biological processes were significantly enriched for the up-methylated genes. (D) The top ten gene ontology terms of biological process significantly enriched for down-methylated genes. (E) In the cellular component category, the lung tissues of rats mainly contain genes with DMMSs. (F) Bar plot showing the top ten enrichment scores of the significant enrichment pathway for the up-methylated genes. (G) Bar plot showing the top ten enrichment scores of the significant enrichment pathways of the down-methylated genes.