Research Paper Volume 13, Issue 13 pp 17473—17488

Activin receptor-like kinase 4 haplodeficiency alleviates the cardiac inflammation and pacing-induced ventricular arrhythmias after myocardial infarction

Upregulated ALK4 expression in peripheral blood mononuclear cells of AMI patients. Flow cytometry analysis of human peripheral blood mononuclear cells were showed. PBMCs were isolated from acute myocardial infarction patient (A) and healthy person (B). ALK4, CD16 and CD14 were detected (n=9, each group). (C) Bar graph presenting the number of ALK4(+) cells in CD16(+) or CD14(+) monocytes in healthy controls and AMI patients, p=0.0011. *P

Figure 1. Upregulated ALK4 expression in peripheral blood mononuclear cells of AMI patients. Flow cytometry analysis of human peripheral blood mononuclear cells were showed. PBMCs were isolated from acute myocardial infarction patient (A) and healthy person (B). ALK4, CD16 and CD14 were detected (n=9, each group). (C) Bar graph presenting the number of ALK4(+) cells in CD16(+) or CD14(+) monocytes in healthy controls and AMI patients, p=0.0011. *P < 0.05 vs. healthy controls. AMI, acute myocardial infarction.