Research Paper Volume 13, Issue 13 pp 17473—17488

Activin receptor-like kinase 4 haplodeficiency alleviates the cardiac inflammation and pacing-induced ventricular arrhythmias after myocardial infarction

ALK4 haplodeficency promotes anti-inflammation response. (A) The mRNA expression of MRC-1, CCL7 and YM-1 were detected in WT and ALK4+/- mice on the 7th day post-MI (n=4 for each). (B) The mRNA expression of Arg, CCL7, Fizz-1, MRC-1 and YM-1 were detected in bone marrow derived macrophages from WT and ALK4+/- mice stimulated by IL-4 in 4 groups (n=4 for each). (C) CD206 expression in WT and ALK4+/- mice on the 7th day post-MI in immunofluorescence (n=4 for each). (D) The quantitative analysis of the CD206 expression in the MI group. * p

Figure 6. ALK4 haplodeficency promotes anti-inflammation response. (A) The mRNA expression of MRC-1, CCL7 and YM-1 were detected in WT and ALK4+/- mice on the 7th day post-MI (n=4 for each). (B) The mRNA expression of Arg, CCL7, Fizz-1, MRC-1 and YM-1 were detected in bone marrow derived macrophages from WT and ALK4+/- mice stimulated by IL-4 in 4 groups (n=4 for each). (C) CD206 expression in WT and ALK4+/- mice on the 7th day post-MI in immunofluorescence (n=4 for each). (D) The quantitative analysis of the CD206 expression in the MI group. * p<0.05. NS: not significant.