Research Paper Volume 14, Issue 11 pp 4673—4698

CXCR4 knockdown enhances sensitivity of paclitaxel via the PI3K/Akt/mTOR pathway in ovarian carcinoma


Figure 6. In vivo evaluating the effects of CXCR4 knockdown and overexpression chemosensitivity of both OVCA420 and SKOV3 tumour cells to PTX treatment in the xenograft tumour nude mouse model. Representative images (day 19) were recorded under macro view representing the size of tumours in the tumour xenograft mice (A, E), when combined with PTX treatment (B, F). Tumour volume (C, G) and body weight (D, H) changes following CXCR4 knockdown and overexpression and, the combined treatment with paclitaxel (PTX) in the OVCA420 and SKOV3 tumour cell xenograft model, respectively. Data represent the means ±S.D. from six nude model mice for each time point examined. Asterisk indicates P< 0.05 compared with the controls as determined by t test.