Research Paper Advance Articles

Glioma stem cell-derived exosomal miR-944 reduces glioma growth and angiogenesis by inhibiting AKT/ERK signaling

Exosomal miR-944 derived from GSCs suppresses proliferation and migration of HUVECs. (A) CCK-8 assay results show viability of HUVECs co-cultured with GSCs/agomiR-NC-Exo and GSCs/agomiR-944-Exo for 24 h. (B, C) Immunofluorescence assay results show the proliferation status of HUVECs co-cultured with GSCs/ agomiR-NC-Exo and GSCs/agomiR-944-Exo for 24 h based on Ki-67 staining. (D, E) Transwell assay results show the migration ability of HUVECs co-cultured with GSCs/agomiR-NC-Exo and GSCs/agomiR-944-Exo for 24 h. **P

Figure 5. Exosomal miR-944 derived from GSCs suppresses proliferation and migration of HUVECs. (A) CCK-8 assay results show viability of HUVECs co-cultured with GSCs/agomiR-NC-Exo and GSCs/agomiR-944-Exo for 24 h. (B, C) Immunofluorescence assay results show the proliferation status of HUVECs co-cultured with GSCs/ agomiR-NC-Exo and GSCs/agomiR-944-Exo for 24 h based on Ki-67 staining. (D, E) Transwell assay results show the migration ability of HUVECs co-cultured with GSCs/agomiR-NC-Exo and GSCs/agomiR-944-Exo for 24 h. **P < 0.01 vs. the GSCs/agomiR-NC-exo group. GSCs, glioma stem cells; HUVECs, human umbilical vein endothelial cells.