Research Paper Volume 13, Issue 13 pp 17536—17547

IGF IIRα-triggered pathological manifestations in the heart aggravate renal inflammation in STZ-induced type-I diabetes rats

Changes in diabetic nephropathy associated Inflammation mediators. Western blotting analysis (n=3) on DM associated inflammatory cytokines showed differences in the levels of TGFβ1, p-stat3, CTGF and TIMP that are associated with fibrosis in kidney, among Non-transgenic rats (NTG), transgenic (TG), NTG-streptozotocin induced diabetes model (NTGSTZ), TG streptozotocin induced diabetes model (TGSTZ). **p0.01 and *** pp0.01 and ### pp0.01 and δδδ p

Figure 6. Changes in diabetic nephropathy associated Inflammation mediators. Western blotting analysis (n=3) on DM associated inflammatory cytokines showed differences in the levels of TGFβ1, p-stat3, CTGF and TIMP that are associated with fibrosis in kidney, among Non-transgenic rats (NTG), transgenic (TG), NTG-streptozotocin induced diabetes model (NTGSTZ), TG streptozotocin induced diabetes model (TGSTZ). **<p0.01 and *** p<0.001 indicate significance when compared to NTG group. ##<p0.01 and ### p<0.001 indicate significance when compared to NTGSTZ group and δδ<p0.01 and δδδ p<0.001 indicate significance when compared to TG group.