Research Paper Volume 13, Issue 13 pp 17536—17547

IGF IIRα-triggered pathological manifestations in the heart aggravate renal inflammation in STZ-induced type-I diabetes rats

Effects of cardiac specific IGFIIRα overexpressing DM rats on apoptosis. STZ induced DM rats show TUNEL positive nuclei (green). IGF2R overexpression in hearts increases the apoptosis rate in kidney (n=3). Scale bar represent 100 μm at 40 x magnification. *** ppp

Figure 7. Effects of cardiac specific IGFIIRα overexpressing DM rats on apoptosis. STZ induced DM rats show TUNEL positive nuclei (green). IGF2R overexpression in hearts increases the apoptosis rate in kidney (n=3). Scale bar represent 100 μm at 40 x magnification. *** p<0.001 indicates significance when compared to NTG group. ### p<0.001 indicates significance when compared to NTGSTZ group and δδδ p<0.001 indicates significance when compared to TG group.