Research Paper Volume 13, Issue 13 pp 17568—17591

Aging-dependent loss of GAP junction proteins Cx46 and Cx50 in the fiber cells of human and mouse lenses accounts for the diminished coupling conductance

Comparison of expression levels of the connexins Cx43, Cx46 and Cx50 in mouse lens epithelial samples of different age groups. (A) Relative expression levels of Cx43, Cx46 and Cx50 in mouse lens epithelial samples of different age groups (1M, 8M and 14M). Each bar represents an average of five or more lens epithelial samples from five or more mice. (B) Summary of age-dependent changes of the connexins Cx43, Cx46 and Cx50 in mouse lenses of different age groups. The levels of the connexins Cx43, Cx46 or Cx50 from 1M old mice are used as references indicated by the star symbol ‘*’. +, ++, and +++ represent increases in protein levels between 0.1% and 24.99%, 25% and 50%, and >50%, respectively; −, −−, and −−− stands for decreases in protein levels between 0.1% and 24.99%, 25% and 50%, and >50%, respectively.

Figure 7. Comparison of expression levels of the connexins Cx43, Cx46 and Cx50 in mouse lens epithelial samples of different age groups. (A) Relative expression levels of Cx43, Cx46 and Cx50 in mouse lens epithelial samples of different age groups (1M, 8M and 14M). Each bar represents an average of five or more lens epithelial samples from five or more mice. (B) Summary of age-dependent changes of the connexins Cx43, Cx46 and Cx50 in mouse lenses of different age groups. The levels of the connexins Cx43, Cx46 or Cx50 from 1M old mice are used as references indicated by the star symbol ‘*’. +, ++, and +++ represent increases in protein levels between 0.1% and 24.99%, 25% and 50%, and >50%, respectively; −, −−, and −−− stands for decreases in protein levels between 0.1% and 24.99%, 25% and 50%, and >50%, respectively.