Research Paper Volume 13, Issue 13 pp 17607—17628

Comprehensive analysis of an immune-related ceRNA network in identifying a novel lncRNA signature as a prognostic biomarker for hepatocellular carcinoma


Figure 10. The role of LINC00491 in HCC. (A) LINC00491 was overexpressed in HCC tissues than that of paracancerous tissues harvested from Zhujiang cohorts. (B) The results of CCK-8 assays in the MHCC-97H cell line and the HLF cell line showed lower absorbance in HCC cells with LINC00491 knockdown at 96h and 120h, respectively. (C) The colony formation assay indicated that LINC00491 silencing significantly suppressed the growth of HCC cells. (D, E) The results of transwell assays showed that LINC00491 silencing significantly suppressed invasion and migration rates of HCC cells. (F) LINC00491 silencing significantly repressed wound healing in HCC cells. (G) The results of cell cycle revealed that LINC00491 depletion significantly inhibited cell cycle progression in MHCC97H and HLF cells. (H) Photographs of the subcutaneous tumors are shown. (I, J) The tumor volumes and weights were measured. * p < 0.05, ** p < 0.01, *** p < 0.001.