Figure 1. Effects of CYP on survival rate of chondrocytes. (A) Structural chemical formula of CYP. (B, C) CYP’s cytotoxicity of in an increasing concentration (0, 0.75, 1.5, 3, 6 μM) on chondrocytes as measured by CCK-8 assay after a 24 or 48-hour incubation. (D) Morphology of chondrocytes as observed under a microscope following treatment by IL-1β (10 ng/ml) combined with or without CYP (3 μM) after 24 hours of incubation (scale bar: 150 μm). Data presented are means ± S.D. of five independent experiments. * p < 0.05 and ** p < 0.01 vs. the control group, n=5.