Figure 5. Apremilast reduced IL-1α-induced expression of IL-1R1 in ESCs. Cells were stimulated with 5 ng/mL IL-1α in the presence or absence of 1.5 or 3 μM Apremilast for 12 hours. (A). mRNA of IL-1R1; (B). Protein of IL-1R1 (****P < 0.0005 vs. vehicle group; #, ##, P < 0.05, 0.01 vs. IL-1α treatment group, N = 5–6).