Research Paper Volume 13, Issue 13 pp 17768—17788

Methylation silencing CDH23 is a poor prognostic marker in diffuse large B-cell lymphoma

Protein-protein interaction network of CDH23 and its target proteins (GeneMANIA). (A) Protein-protein interaction network of CDH23. The gene set enriched in the target network of CDH23 was explored via Protein-protein interaction (PPI) network and functional analysis. Distinct colors of the network edge indicate the bioinformatic methods applied: physical interactions, co-expression, predicted, co-localization, pathway, genetic interactions and shared protein domains. The distinct colors for the network nodes show the biological functions of the sets of enrichment genes, including cell-cell adhesion, adherens junction organization, microvillus, neuromuscular process, sensory perception of sound and photoreceptor cell maintenance. (B) Protein-protein interaction network of CDH23 target proteins, including CDK1, CDK2, E2F1 and E2F4. Distinct colors of the network edge indicate the bioinformatic methods applied: physical interactions, co-expression, predicted, co-localization, pathway, genetic interactions and shared protein domains. The distinct colors for the network nodes show the biological functions of the sets of enrichment genes, including cell cycle checkpoint, regulation of cell cycle phase transition, DNA damage checkpoint, DNA integrity checkpoint, response to transforming growth factor beta, Ras protein signal transduction and nucleus organization.

Figure 7. Protein-protein interaction network of CDH23 and its target proteins (GeneMANIA). (A) Protein-protein interaction network of CDH23. The gene set enriched in the target network of CDH23 was explored via Protein-protein interaction (PPI) network and functional analysis. Distinct colors of the network edge indicate the bioinformatic methods applied: physical interactions, co-expression, predicted, co-localization, pathway, genetic interactions and shared protein domains. The distinct colors for the network nodes show the biological functions of the sets of enrichment genes, including cell-cell adhesion, adherens junction organization, microvillus, neuromuscular process, sensory perception of sound and photoreceptor cell maintenance. (B) Protein-protein interaction network of CDH23 target proteins, including CDK1, CDK2, E2F1 and E2F4. Distinct colors of the network edge indicate the bioinformatic methods applied: physical interactions, co-expression, predicted, co-localization, pathway, genetic interactions and shared protein domains. The distinct colors for the network nodes show the biological functions of the sets of enrichment genes, including cell cycle checkpoint, regulation of cell cycle phase transition, DNA damage checkpoint, DNA integrity checkpoint, response to transforming growth factor beta, Ras protein signal transduction and nucleus organization.