Research Paper Volume 13, Issue 15 pp 19306—19316

LncRNA-HAGLR motivates triple negative breast cancer progression by regulation of WNT2 via sponging miR-335-3p

The expression of lncRNA HAGLR in TNBC tissues and cells. We collected 40 samples of patients diagnosed with TNBC. (A) The expression of HAGLR in para-carcinoma and cancer tissues was detected by qRT-PCR. (B) qRT-PCR analysis for HAGLR level in normal breast cell MCF10A and TNBC cell lines MDA-MB-231 and BT549. (C) According to the mean level of HAGLR in Figure 1A, 40 TNBC patients was divided into low (n = 20) and high expression group (n = 20). Kaplan-Meier curves indicated 5-year survival rate of TNBC patients. (D) Another 40 TNBC patients were collected, which includes grade 0 to grade IV of TNBC (n = 8 for each grade), and qRT-PCR was used to test HAGLR level in different grades. Data are mean ± SD; *P **P

Figure 1. The expression of lncRNA HAGLR in TNBC tissues and cells. We collected 40 samples of patients diagnosed with TNBC. (A) The expression of HAGLR in para-carcinoma and cancer tissues was detected by qRT-PCR. (B) qRT-PCR analysis for HAGLR level in normal breast cell MCF10A and TNBC cell lines MDA-MB-231 and BT549. (C) According to the mean level of HAGLR in Figure 1A, 40 TNBC patients was divided into low (n = 20) and high expression group (n = 20). Kaplan-Meier curves indicated 5-year survival rate of TNBC patients. (D) Another 40 TNBC patients were collected, which includes grade 0 to grade IV of TNBC (n = 8 for each grade), and qRT-PCR was used to test HAGLR level in different grades. Data are mean ± SD; *P < 0.05, **P < 0.01.