Research Paper Volume 13, Issue 16 pp 20131—20148

Immune normalization strategy against suboptimal health status: safe and efficacious therapy using mixed-natural killer cells

NKM cells have very high in vitro cytotoxicity. (A) The cytotoxicity of PBMCs and NKM cells. The cytotoxicity of 9 PBMCs (incubation for 2 h) and 28 PBMCs (incubation for 4 h) was obtained. The cytotoxicity of 198 NKM cells (incubation for 2 h) was obtained. (B, C) Labeled target cells (K562 cancer cells) were killed by effector cells (PBMC or NKM). The number on the upper right shows the cytotoxicity of effector cells. The ratio of effector cells: target cells was 10:1 or 20:1, and the incubation time was 2 h or 4 h.

Figure 2. NKM cells have very high in vitro cytotoxicity. (A) The cytotoxicity of PBMCs and NKM cells. The cytotoxicity of 9 PBMCs (incubation for 2 h) and 28 PBMCs (incubation for 4 h) was obtained. The cytotoxicity of 198 NKM cells (incubation for 2 h) was obtained. (B, C) Labeled target cells (K562 cancer cells) were killed by effector cells (PBMC or NKM). The number on the upper right shows the cytotoxicity of effector cells. The ratio of effector cells: target cells was 10:1 or 20:1, and the incubation time was 2 h or 4 h.