Research Paper Volume 13, Issue 13 pp 16922—16937

A model of the aged lung epithelium in idiopathic pulmonary fibrosis

7-day bleomycin protocol leads to loss of proteostasis in alveolar epithelial cells. (A, B) Proteostat staining (aggresome) in controls and chronically injured MLE12 cells. Quantification is shown on the right. (C–E) Chymotrypsin-like, trypsin-like and caspase-like activities in control and bleomycin injured MLE12 cells. Statistical significance was assessed by Student t-test **P

Figure 5. 7-day bleomycin protocol leads to loss of proteostasis in alveolar epithelial cells. (A, B) Proteostat staining (aggresome) in controls and chronically injured MLE12 cells. Quantification is shown on the right. (CE) Chymotrypsin-like, trypsin-like and caspase-like activities in control and bleomycin injured MLE12 cells. Statistical significance was assessed by Student t-test **P < 0.01, ***P < 0.001 versus control group, n=6.