Research Paper Volume 13, Issue 13 pp 16922—16937

A model of the aged lung epithelium in idiopathic pulmonary fibrosis

7-day bleomycin protocol reduces NRF-1 expression in alveolar epithelial cells. (A) WB for NRF1 in control and bleomycin injured cells (with β-actin loading control). Densitometry is shown on the right. (B) Transcript levels for PSMD10, PSMD12, PSMD5, PSMD11, and PSMB6/β1 in controls vs. injured MLE12 cells. Statistical significance was assessed by unpaired Student’s t-test for two groups. * p

Figure 6. 7-day bleomycin protocol reduces NRF-1 expression in alveolar epithelial cells. (A) WB for NRF1 in control and bleomycin injured cells (with β-actin loading control). Densitometry is shown on the right. (B) Transcript levels for PSMD10, PSMD12, PSMD5, PSMD11, and PSMB6/β1 in controls vs. injured MLE12 cells. Statistical significance was assessed by unpaired Student’s t-test for two groups. * p< 0.05, **P < 0.01, ***P < 0.001 versus control group, n=6.