Research Paper Volume 13, Issue 14 pp 18464—18481

Fibroblastic galectin-1-fostered invasion and metastasis are mediated by TGF-β1-induced epithelial-mesenchymal transition in gastric cancer


Figure 5. GAL-1/ LGALS1 induces EMT through TGF-β/Smad signaling pathways in vitro. (A, B) WB showing that OE-LGALS1 efficiently increased the expression of TGF-β1 and p-Smad2/3 and induced EMT in MGC-803 and SGC-7901 cells compared with the wild-type cells (all P < 0.01). (C, D) Silencing LGALS1 in MGC-803 and SGA-7901 cells efficiently decreased the levels of TGF-β1 and p-Smad2/3 and inhibited EMT (all P < 0.01).