Research Paper Advance Articles

Fibroblastic galectin-1-fostered invasion and metastasis are mediated by TGF-β1-induced epithelial-mesenchymal transition in gastric cancer

GAL-1/ LGALS1 promotes the migration and invasion of GC cells in vitro through TGF-β/Smad signaling pathways. (A–D) OE-LGALS1 significantly enhanced the migration capacity of MGC-803 and SGC-7901 cells compared with WC and OE-con. The migration capacity was abolished when the medium contained 10 μM ITD1 (P E) Transwell assay showing that MGC-803 and SGC-7901 cells increased their invasive ability after transfection with LV-LGALS1-OE, and 10μM ITD1 abolished this increase in invasive ability (n = 3). Magnification: ×200.

Figure 6. GAL-1/ LGALS1 promotes the migration and invasion of GC cells in vitro through TGF-β/Smad signaling pathways. (AD) OE-LGALS1 significantly enhanced the migration capacity of MGC-803 and SGC-7901 cells compared with WC and OE-con. The migration capacity was abolished when the medium contained 10 μM ITD1 (P < 0.01). Magnification: ×40. (E) Transwell assay showing that MGC-803 and SGC-7901 cells increased their invasive ability after transfection with LV-LGALS1-OE, and 10μM ITD1 abolished this increase in invasive ability (n = 3). Magnification: ×200.