Figure 4. ZC3HAV1 knockdown decreases the proliferation of pancreatic cancer in vivo. (A) In the end of the experiment, all tumors were resected and the tumors in the ZC3HAV1-silencing groups apparently appeared to be smaller than those in the control group. (B) The volumes of the tumor were measured every week. (C) The weight of mice in the ZC3HAV1 knockdown and sh-NC group was detected every week. (D) In the end of experiment, the weight of the xenografts were measured. (E, F) The expression of Ki67 along with PCNA in xenografts was detected through immunohistochemical staining (scar bar: 100 μm). Data speared to be mean ± SD, *P< 0.05, **P< 0.01.