Research Paper Volume 13, Issue 14 pp 18482—18497

ZC3HAV1 promotes the proliferation and metastasis via regulating KRAS in pancreatic cancer

ZC3HAV1 regulates the ERK pathway by targeting KRAS. (A, B) KRAS correlation with ZC3HAV1 and its associated with overall survival were predicted by starBase. (C) The expression of KRAS in PC tissues compared with adjacent normal tissues with basis of the GEPIA database. (D, E) GO analysis of KRAS was performed. (F) ZC3HAV1 protein was immunoprecipitated with ZC3HAV1 antibody and levels of bound KRAS were found by western blotting. (G, H) Protein expression levels of vital modulators of the ERK signaling pathway and dissected KRAS by western blotting.

Figure 5. ZC3HAV1 regulates the ERK pathway by targeting KRAS. (A, B) KRAS correlation with ZC3HAV1 and its associated with overall survival were predicted by starBase. (C) The expression of KRAS in PC tissues compared with adjacent normal tissues with basis of the GEPIA database. (D, E) GO analysis of KRAS was performed. (F) ZC3HAV1 protein was immunoprecipitated with ZC3HAV1 antibody and levels of bound KRAS were found by western blotting. (G, H) Protein expression levels of vital modulators of the ERK signaling pathway and dissected KRAS by western blotting.