Research Paper Advance Articles

Agomelatine prevents angiotensin II-induced endothelial and mononuclear cell adhesion

The effects of agomelatine in Ang II-induced attachment of THP-1 monocytes to HUVECs. HUVECs were treated with Ang II (1 μM) with or without agomelatine (10, 20 μM) for 24 h. Calcein-AM staining method was used to measure attachment of THP-1 cells to HUVECs (##, **, &&, P

Figure 3. The effects of agomelatine in Ang II-induced attachment of THP-1 monocytes to HUVECs. HUVECs were treated with Ang II (1 μM) with or without agomelatine (10, 20 μM) for 24 h. Calcein-AM staining method was used to measure attachment of THP-1 cells to HUVECs (##, **, &&, P<0.01 vs. vehicle control, Ang II, Ang II+ 10 μM agomelatine group).