Research Paper Advance Articles

Agomelatine prevents angiotensin II-induced endothelial and mononuclear cell adhesion

The effects of agomelatine in Ang II-induced chemokine production in HUVECs. HUVECs were treated with Ang II (1 μM) with or without agomelatine (10, 20 μM) for 24 h. (A) mRNA of CXCL1, MCP-1, and CCL5; (B) Protein of CXCL1, MCP-1, and CCL5 (##, **, &&, P

Figure 4. The effects of agomelatine in Ang II-induced chemokine production in HUVECs. HUVECs were treated with Ang II (1 μM) with or without agomelatine (10, 20 μM) for 24 h. (A) mRNA of CXCL1, MCP-1, and CCL5; (B) Protein of CXCL1, MCP-1, and CCL5 (##, **, &&, P<0.01 vs. vehicle control, Ang II, Ang II+ 10 μM agomelatine group).