Research Paper Volume 13, Issue 14 pp 18515—18526

Agomelatine prevents angiotensin II-induced endothelial and mononuclear cell adhesion


Figure 5. The effects of agomelatine in Ang II-induced proinflammatory cytokine production in HUVECs. HUVECs were treated with Ang II (1 μM) with or without agomelatine (10, 20 μM) for 24 h. (A) mRNA of TNF-α, IL-12, and IL-8; (B) Protein of TNF-α, IL-12, and IL-8 (##, **, &&, P<0.01 vs. vehicle control, Ang II, Ang II+ 10 μM agomelatine group).