Research Paper Volume 13, Issue 14 pp 18586—18605

Circular RNA circSP3 promotes hepatocellular carcinoma growth by sponging microRNA-198 and upregulating cyclin-dependent kinase 4

CircSP3 induced HCC cell proliferation in vitro. (A) A CCK-8 assay was performed to assess cell proliferation when circSP3 was overexpressed in Hep-3B cells. (B) A CCK-8 assay was performed to assess cell proliferation when circSP3 was knocked down in Huh-7 cells. (C) The cell cycle was analyzed using flow cytometry when circSP3 was overexpressed or knocked down. *p

Figure 4. CircSP3 induced HCC cell proliferation in vitro. (A) A CCK-8 assay was performed to assess cell proliferation when circSP3 was overexpressed in Hep-3B cells. (B) A CCK-8 assay was performed to assess cell proliferation when circSP3 was knocked down in Huh-7 cells. (C) The cell cycle was analyzed using flow cytometry when circSP3 was overexpressed or knocked down. *p<0.05, **p<0.01 and ***p<0.001.