Research Paper Volume 13, Issue 14 pp 17978—18005

HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts

Summary about the role of HDACs in the senescent phenotype of dermal fibroblasts. During replicative senescence of skin cells, HDACs protein abundance is reduced. The inhibition of HDACs with the use of SAHA, a pan-HDACs inhibitor, as well as the targeted knockdown of HDAC2 or HDAC7 by siRNA induce premature senescence. Moreover, the re-expression of HDAC7, but not HDAC2, in pre-senescent fibroblasts allows the extension of their proliferative lifespan. Finally, the effect of HDACs inhibition on IL-6 and IL-8 expression is partly dependent on NF-κB activation.

Figure 6. Summary about the role of HDACs in the senescent phenotype of dermal fibroblasts. During replicative senescence of skin cells, HDACs protein abundance is reduced. The inhibition of HDACs with the use of SAHA, a pan-HDACs inhibitor, as well as the targeted knockdown of HDAC2 or HDAC7 by siRNA induce premature senescence. Moreover, the re-expression of HDAC7, but not HDAC2, in pre-senescent fibroblasts allows the extension of their proliferative lifespan. Finally, the effect of HDACs inhibition on IL-6 and IL-8 expression is partly dependent on NF-κB activation.