Research Paper Volume 13, Issue 14 pp 18606—18619

Obesity increases neuropathic pain via the AMPK-ERK-NOX4 pathway in rats

Inhibition of ERK activation reduces obesity-induced increases in neuropathic pain. (A) The body weight of rats was measured at different time points. (B) The protocol of Part 1. (C) Allodynia in the NCCD and OCCD groups was detected by the PWMT test at the indicated time points after CCD surgery. (D) The role of ERK inhibition on PWMT in obese CCD rats after intrathecal injection. N = 10-15 per group. **P ##P

Figure 1. Inhibition of ERK activation reduces obesity-induced increases in neuropathic pain. (A) The body weight of rats was measured at different time points. (B) The protocol of Part 1. (C) Allodynia in the NCCD and OCCD groups was detected by the PWMT test at the indicated time points after CCD surgery. (D) The role of ERK inhibition on PWMT in obese CCD rats after intrathecal injection. N = 10-15 per group. **P < 0.01 vs. con or NCCD group, ##P < 0.01 vs. OCCD + saline group. U0126, ERK inhibitor; ERK, extracellular-regulated kinase; AMPK, AMP-activated protein kinase; CCD, chronic compression of the dorsal root ganglia; NCCD, normal CCD; OCCD, obese CCD; PWMT, paw withdrawal mechanical threshold.