Research Paper Volume 13, Issue 17 pp 21102—21121
Bortezomib enhances the anti-cancer effect of the novel Bruton’s tyrosine kinase inhibitor (BGB-3111) in mantle cell lymphoma expressing BTK
Figure 1. BTK expression in the MCL patients and the benign lymphoid tissues. (A) ×100 magnification and (B) ×400 magnification, Representative patterns of BTK expressing limitedly in the germinal center cells of the mantle zone in the tonsils. (C) ×100 magnification and (D) ×400 magnification, Representative patterns of low BTK expression with less than one-quarter positive staining proportion in the MCL patient tissues. (E) ×100 magnification and (F) ×400 magnification, Representative patterns of high BTK expression with widely broken and disappeared germinal center in the MCL patient tissues.